We've established in the past that Conan O'Brien messes up well-known chefs during cooking demonstrations, but in this case Jose Andres messed up the segment himself. Andres seemed a bit off and kooky during his appearance.
He made a cocktail using a power drill, then made a Buddha taking a bath. He said that coconuts talk to him and spoke of walking on the beach with his Black & Decker drill and syringe. There's also lots of sexual innuendo.